The crossing itself is one of the better cheap thrills in southern Iberia. A small car and passenger ferry works the river between Vila Real de Santo António and Ayamonte in about fifteen minutes; it typically runs through the day with more sailings in summer, and it can be suspended in bad weather or strong currents, so check before committing. Vila Real is the eastern terminus of the Algarve railway, so the whole thing is doable without a car: train from Faro, walk to the pier, ferry, then regional buses onward from Ayamonte towards Huelva and Seville.
Ayamonte rewards an afternoon rather than a day — a marina, a shaded main square, tapas bars that fill late. The beaches at Isla Canela and Punta del Moral are flat, wide and far less built up than the central Algarve. Push west along the coast to Isla Cristina, a working fishing port whose prawns are the reason half of Seville drives down at weekends.
Huelva city is honest, industrial and not especially pretty, but two things make the detour worth it: the long iron ore pier curving into the estuary, built by the British-run mining company that once owned this stretch of the province, and the Barrio Reina Victoria, a district of English-style workers' housing that looks as though it was airlifted from Surrey. Both are free to walk around. Just south, at Palos de la Frontera, the Monasterio de La Rábida and the full-size ship replicas moored at the Muelle de las Carabelas cover the Columbus departure story properly, without the theme-park tone.
The hills behind the coast
The best of Huelva province is inland. The Parque Minero de Riotinto, about an hour and a quarter north of the city, is an open-cast mining landscape of red rock and a river that runs the colour of rust; there is a museum, a restored miners' railway and a separate underground shaft to visit, and tours are timed, so book. Another forty minutes on, Aracena sits in the Sierra de Aracena y Picos de Aroche, a green range of chestnut woods and whitewashed villages that is markedly cooler than the coast in high summer. Its cave system, the Gruta de las Maravillas, runs guided visits with limited capacity that regularly sell out in the middle of the day — go early or reserve. The village of Jabugo below produces the acorn-fed ham that Spain treats as a national asset, and Almonaster la Real keeps a small tenth-century mosque inside its hilltop fortress. Two nights here is not too many.
Doñana, with realistic expectations
The Doñana wetlands, a UNESCO World Heritage site, sit between Huelva and Seville, and you do not simply drive in. Access to the core is controlled and the practical route for most visitors is an official guided vehicle tour from the main visitor centre near Matalascañas, booked ahead. Time it right: the marshes shrink through late summer and the birdlife is at its best from autumn through spring. Nearby El Rocío, with its sand streets and horse rails, is worth an hour at any time — except at Pentecost, when the pilgrimage arrives and the roads for miles around become impassable.
You can drive Faro to Seville in around two and a half hours and direct coaches run the route in roughly three; either way, a day trip means arriving at the hottest hour and leaving before the city wakes up. Give it two nights, three if you can. The Real Alcázar and the cathedral with its Giralda tower both use timed tickets that go early in season — buy them before you travel, not on the morning. Plaza de España, the Triana district across the river with its covered market, and the Museo de Bellas Artes fill the gaps comfortably.
The honest caveat is heat. July and August in Seville regularly push past the high thirties, and afternoons are for a shuttered room. If your Algarve week falls in high summer, consider doing Seville at the front or back of the trip in a shoulder month, or accept a schedule of monuments at opening, siesta, and life resuming after dark. Parking in the centre is miserable; leave the car in a garage on the ring or come by bus.